During inflammation, macrophages secrete pro-inflammatory cytokines, such as TNF-α and interleukin-6 (Il6), thereby downregulating GLUT-4 in both myocytes and adipocytes, leading to a decrease glucose uptake of those cells in inflamed SM, which is also involved with the development of insulin resistance [24,28,29]. The gene discussed is SLC2A4; the disease is Insulin resistance.