Microarray gene chip analysis of a highly aggressive compared with poorly aggressive human cutaneous melanoma cell lines revealed a significant increase in the expression of laminin 5 and matrix metalloproteinases-1, -2, and -9 (MMP-1, MMP-2, MMP-9) and MT1-MMP in the highly aggressive cells [76], suggesting that increased expression of MMP-2 and MT1-MMP along with matrix deposition of laminin 5 are required for their mimicry. This evidence concerns the gene MMP2 and cutaneous melanoma.