FOXO1 and neoplasm: It is able to induce apoptosis and inhibit proliferation in T790M-positive NSCLC cell lines; upregulate the expression of forkhead box protein O1 (FoxO1); downregulate the long lncRNA colon cancer-associated transcript 1 (CCAT1) levels in T790M-positive NSCLC cell lines; and repress the tumor growth of T790M-positive NSCLC xenografts [150].