TRPC6 and pulmonary fibrosis: In the lung, TRPC6 is highly expressed in vascular endothelia, precapillary pulmonary arterial smooth-muscle cells (PASMC), neutrophils and myofibroblasts, where it is associated with numerous pathophysiological pulmonary alterations, such as hypoxic vasoconstriction, pulmonary hypertension, lung ischemia-reperfusion edema (LIRE, a main reason for lung transplant failure and lung embolism), or lung fibrosis [8,9].