TARDBP and early-onset autosomal dominant Alzheimer disease: The most common protein inclusion in ALS is TDP-43 (encoded by the TARDBP gene) [32]; however, TDP-43 deposits have been observed in other neurodegenerative diseases such as Alzheimer’s disease (A.D.)[37,38], Lewy bodies dementia (DLB) [39,40], and corticobasal degeneration (CBD) [38,41].