OPTN and amyotrophic lateral sclerosis: Mutations in several autophagy genes have been associated with ALS, including Sequestosome 1 (SQSTM1), SOD1, optineurin (OPTN), valosin-containing protein (VCP), ubiquitin-2 (UBQLN2), and TANK-binding kinase 1 (TBK1) [55].