CHCHD10 and amyotrophic lateral sclerosis: Direct evidence that disruption of mitochondrial structure (and as a result disruption of mitochondrial function; see below) may contribute to the etiology of ALS comes from the discovery of causative mutations in the mitochondrial protein Coiled-coil-helix-coiled-coil-helix domain-containing protein 10 (CHCHD10); this protein is localized to contact sites between the inner and outer mitochondrial membrane [68].