EWSR1 and amyotrophic lateral sclerosis: Variations in the genes of other ALS-linked RNA-binding proteins, including TATA-box binding protein associated factor 15 (TAF15), senataxin (SETX), and RNA-binding protein EWS (EWSR1), have also been linked to impaired DNA damage repair, further implicating the breakdown of this process in ALS pathogenesis [74,75,76].