By using this approach, we have identified 3 anti-fungal drugs (i.e., econazole, clotrimazole, and fenticonazole) and 1 antibiotic (i.e., tigecycline) and further characterized the effect of Clo and Fenti because these two drugs affect ERα signaling in cellular models of primary (i.e., MCF-7) and metastatic (i.e., Y537S) BC cells. This evidence concerns the gene ESR1 and breast cancer.