As it has been previously suggested that release of norepinephrine by the sympathetic nervous system can induce reactivation of dormant DTC via suppression of Gas6 [302], and that propranolol remained effective in upregulating Gas6 expression even in the presence of norepinephrine [255], these findings suggest that treatment of patients at high risk of developing bone metastasis could benefit from adjuvant use of propranolol. This evidence concerns the gene GAS6 and bone metastasis.