Although the authors did not examine the effects of AMD3465 directly on tumor cell dormancy, they did observe that treatment with AMD3465 resulted in decreased numbers of intra-tumoral MDSC and Tregs and that systemic depletion of CD8+ and CD4+ T-cells allowed for tumor growth in the presence of AMD3465; these findings support the author’s contention that the anti-tumor drug efficacy was in part mediated by alleviating immunosuppression and promoting anti-tumor immunity in the tumor microenvironment. This evidence concerns the gene CD8A and neoplasm.