SelectMDx measures the mRNA levels of homeobox C6 (HOXC6, which regulates several oncogenes and tumor suppressor genes implicated in prostate morphogenesis and bone metastasis) and distal-less homeobox 1 (DLX1, which regulates neuroendocrine-epithelial differentiation and predicts PCa aggressiveness) in urine samples after DRE. The gene discussed is HOXC6; the disease is posterior cortical atrophy.