To determine whether a genetic model of immunodeficiency or diabetic obese mice affected the recruitment of immune cells in a PVA sponge model of cutaneous injury, we first examined non-obese diabetic (NOD) severe combined immune deficient mice that have a spontaneous mutation of the Prkdc gene (NOD scid mice) and lack functional T and B cells [35]. The gene discussed is PRKDC; the disease is immune system disorder.