SOD1 and hepatocellular carcinoma: We previously reported that SOD1-deficient mice showed the accumulation of oxidative molecules and several age-related pathological changes, including macular degeneration [7,8], hemolytic anemia with splenomegaly [9], osteopenia [10,11], skin atrophy [12], skeletal muscle atrophy [13], hepatic carcinoma [14], and fatty liver [15].