SMAD2 and colorectal carcinoma: The increase (by L1) and decrease in PLOD2 expression (by shPLOD2 and shEzrin) was paralleled by a similar change in SMAD2/3 levels (Figure 5C, compare the SMAD2/3 levels to PLOD2 in L1-expressing and in L1 + shPLOD2 and L1 + shEzrin CRC cells).