The ability of L1 to confer liver metastasis in CRC cells was entirely dependent on PLOD2 expression, since the suppression of PLOD2 levels with shRNA to PLOD2 (Figure 4, L1 + shPLOD2) in L1-transfected cells, or the interference with PLOD2 enzymatic activity using the dominant-negative PLOD2 mutant [Figure 4, L1 + PLOD2 (D689A)], both blocked the metastatic capacity of L1-transfected CRC cells. The gene discussed is PLOD2; the disease is colorectal carcinoma.