PLOD2 and colorectal carcinoma: The suppression of endogenous PLOD2 activity in L1 overexpressing cells by the dominant negative PLOD2(D689A) mutant resulted in the suppression of the tumorigenic activity of L1-expressing CRC cells [Figure 3A,B, compare L1 + PLOD2(D689A) cl1 and cl2 to L1].