Since inhibitors of PLOD2 expression (minoxidil and berberine), and antifibrosis drugs, such as silibrin and pirfenodone, that regulate collagen organization, have already proven their efficacy in the treatment of various cancers [27], the expression of PLOD2 might prove to be a credible prognostic target in the treatment of the L1-mediated promotion of CRC invasion and metastasis. Here, PLOD2 is linked to cancer.