Moreover, the exact roles of most selenoproteins in metabolic disorders and antioxidant responses induced by dietary Se deficiency and excess remain to be further studied, except several well-characterized selenoproteins, such as GPxs and TrxRs, which catalyze redox reactions, and SELENOP which mediates Se transport and metabolism within the tissues [1,50]. The gene discussed is SELENOS; the disease is Other metabolic disease.