In humans, the baseline expression of NMRK2 gene, 800 reads per kilobase per million (Rpkm) in non-failing heart (Figure 1I) is higher than in mice (Figure 1H, see wildtype (WT) controls), and the increase in expression is more modest in human DCM patients [31]. Here, NMRK2 is linked to familial dilated cardiomyopathy.