LRRK2 partially co-localized with MFN1, MFN2 and OPA1 at mitochondrial membranes of neural cells, and WT and PD-associated mutants of LRRK2 (R1441C, Y1699C, and G2019S) could be co-immunoprecipitated with MFN1 [138]. Here, LRRK2 is linked to Parkinson disease.