SOX2 and neoplasm: In the latter, high levels of SOX2 are associated with GSCs and lower patient survival and its activity is required for tumor maintenance and progression, because silencing of the gene in GBM cells reduces the capacity to proliferate, migrate and self-renew, whereas SOX2 overexpression promotes an increase in cell proliferation, migration and self-renewal capacity [3,10,11,12,13,14,15].