The increases in miR-221/222 are highly relevant to the active cell proliferation, EMT process, and metastatic activity in BC cells via targeting a variety of tumor suppressors, including Transcriptional Repressor GATA Binding 1, Adiponectin Receptor 1, Suppressor of Cytokine Signaling 1, Cyclin Dependent Kinase Inhibitor 1B, ERα, p27, and TIMP Metallopeptidase Inhibitor 3 genes [93]. The gene discussed is ESR1; the disease is breast cancer.