ALB and major depressive disorder: After the inclusion of all significant variables from the aforementioned analyses and those clinically relevant into multivariate analyses, we confirmed that higher HRQoL scores (OR 1.3; p < 0.001) predicted the development of depression in HD patients while having a partner (OR 0.3; p = 0.025) and serum albumin levels (OR 0.1; p = 0.027) were associated with a lower presence of this condition (Table 3).