These growth factors bind with high affinity to their cognate tyrosine kinase receptors (VEGFR, EGFR, FGFR, and PDGFR), which play pivotal roles in angiogenesis, tumor growth, and survival, and are associated with poor prognosis, high metastasis, and lower overall survival and disease-free survival [9,20]. The gene discussed is KDR; the disease is neoplasm.