Suppression of NKG2D ligands on LSCs specifically can be overcome by poly (ADP-ribose) polymerase 1 (PARP1) inhibition [81] PARP1 inhibition has also been shown to induce death receptor 5 (DR5) on AML blasts, sensitizing to killing by TRAIL [190]. Here, PARP1 is linked to acute myeloid leukemia.