For example, the estimated five-year overall survival probability after surgery without any adjuvant treatment for a 56-year-old postmenopausal women diagnosed with 48-mm ductal breast cancer with evidence of pathological stage II, tumor histological grade III, two positive lymph nodes, lymphovascular invasion, positive ER and PR status and negative HER-2 status was 62.8%. Here, ERBB2 is linked to neoplasm.