Also, mass spectrometry analyses by Ishizuya et al. revealed 787 exosomal proteins, including Alpha-2-Macroglobulin (A2M), Immunoglobulin Heavy Constant Mu (IGHM), Calcium Release Activated Channel Regulator 2A (CRACR2A), Complement C1q Tumor Necrosis Factor-Related Protein 3 (C1QTNF3), CAMP Responsive Element Binding Protein 3 (CREB3), and Upstream Binding Transcription Factor (UBTF), from sera of 36 men with castration-resistant prostate cancer (CRPC), which may be contributing to PCa disease progression to CRPC [45]. Here, CREB3 is linked to posterior cortical atrophy.