GRN and posterior cortical atrophy: Interestingly, among these lists of proteins, proteins such Charged multivesicular body protein 4a (CHMP4A), Charged multivesicular body protein 4c (CHMP4C), and Charged multivesicular body protein 2b (CHMP2B) which are components of ESCRT-III alongside proteins such as Granulin Precursor (GRN) and Alpha-1 microglycoprotein (AMBP) were found to be overexpressed in men with a Gleason Score of 8–9 suggesting that these proteins may con-tribute to dramatic PCa progression and metastasis [44].