In addition, although there were no significant changes in the protein expression levels of ITGA2 in 24 primary PCa tissues verses their matched metastatic lymph node tissues, lymph node metastatic tissues with a high Gleason Score of 9 was observed to have increased expression of ITGA2 in comparison with PCa tissues with lower Gleason Score of 7, indicating the likely role of ITGA2 in enhancing lymph node metastasis [142]. This evidence concerns the gene ITGA2 and posterior cortical atrophy.