The core kinase Hippo pathway components are regulated by numerous upstream proteins, e.g., neurofibromin 2 (NF2), TAOKs and KIBRA, thereby linking the Hippo pathway to multiple aspects of cancer, such as cell size and proliferation, tissue regeneration, immunity, metabolism, epithelial-to-mesenchymal transition (EMT), and cancer therapy resistance and metastasis [7]. This evidence concerns the gene NF2 and cancer.