Epidemiological studies unraveled relative risks for renal cell carcinoma, including genetic and environmental factors; e.g., a growing body of evidence exhibits high susceptibility of patients, with inherited conditions such as the Von Hippel Lindau (VHL) and Birt–Hogg–Dubé (BHD) syndromes, to renal cell carcinoma [13,14]. The gene discussed is VHL; the disease is renal cell carcinoma.