TGFB1 and Hepatic fibrosis: By contrast, the high expression of ADAMTS1 in cirrhotic tissues [63], the up-regulation of ADAMTS1 in liver fibrosis [69] and the implication of ADAMTS1 in TGF-β activation in activated hepatic stellate cells (HCS) [68] suggest a role of ADAMTS1 in liver fibrosis that might favor tumor onset.