For the third gene, zinc finger and BTB domain-containing protein 7C (ZBTB7C), UniProt contains the entry “May be a tumor suppressor gene.” Therefore, both the large node for tumor necrosis factor and one of the small nodes for ZBTB7C indicate the global semantic axis in obesity research: cancer, which is a frequent companion of inflammation [19]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.