CRH and alcohol dependence: We detected strong alterations in the well-known direct targets of ethanol [42], such as gene clusters related to the GABAergic, glutamatergic, dopaminergic, endocannabinoid-mediated and corticotropin releasing factor (CRF)-related neurotransmission, but also provided evidence about the extended profile of alterations in addition to well characterized molecular targets, many of them also overlapped with the significant findings from recent GWAS studies for alcohol dependence or related phenotypes.