INS and major depressive disorder: Nevertheless, numerous side effects of OC intake have been described [3], including alterations of triglyceride and lipoprotein concentrations [4], increased risk of venous thrombosis [5] by modulating procoagulant and fibrinolytic factors [6,7], reduced insulin sensitivity [8], elevated cortisol concentrations [9,10,11] and a higher risk of depression [12].