CLU and preeclampsia: The specificity of clusterin expression for syncytiotrophoblast cells and chorionic villus endothelium has been proven [30], and its increased expression was also found in preeclampsia both in the placenta [30] and in peripheral blood plasma [31], the key pathogenetic mechanism of which is dysregulation of the phenotypic transformation of trophoblast cells and a reduction in their invasive ability.