The data obtained in thе present work significantly contribute to improvements in the accuracy of AIP diagnosis by instrumental methods [75] and the analysis of placental and fetal hormones (pregnancy-associated plasma protein A, human chorionic gonadotropin, alpha-fetoprotein) by cell-free placental mRNAs [49] as well as by recently discovered plasma marker miRNAs, in particular, miR-139-3p, miR-196a-5p, miR-518a-3p, and miR-671-3p, which are downregulated in placenta increta/percreta and have the potential to be used for future noninvasive prenatal placenta accreta spectrum screening [76]. The gene discussed is PAPPA; the disease is autoimmune pancreatitis.