Thus, in AIP cases characterized by increased invasion of extravillous trophoblast cells, we identified expression profiles of hsa-miR-21-5p, hsa-miR-25-3p, hsa-miR-92a-3p, hsa-miR-320a-3p, and hsa-miR-17-5p and their target gene clusterin that were directly opposite to those seen in preeclampsia, the pathogenesis of which is based on reduced invasion of extravillous trophoblast cells. This evidence concerns the gene CLU and preeclampsia.