NOTCH3 and early-onset autosomal dominant Alzheimer disease: Similarly, the highly active chromosome 19 contains genes such as APOE and Notch 3, whose polymorphisms have implications in, respectively, Alzheimer’s disease (AD) [47,48] and stroke and dementia associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [49,50].