TNF and chronic rhinosinusitis without nasal polyps: Those with a type 2 eosinophilic inflammation account for about 80% of patients with nasal polyposis, whereas CRSsNP, often characterized by type 1 or type 3 inflammation, is associated with the presence of neutrophils and is regulated by elevated levels of IL-6, IL-8, IL-17, and tumor necrosis factor (TNF)-α [17,18,19].