IL4 and chronic rhinosinusitis with nasal polyps: Taking into account the complex, but the partial interplay between eosinophilic inflammation, remodeling, and the role of the various type 2 cytokines, increasing attention has been dedicated to IL-4 and IL-13, which have been clearly identified as preferential therapeutic targets as they play a central and driving role in the pathogenesis of type 2 inflammation in BA, and CRSwNP [76,77].