In this study, we evaluated the functional effect of cassiaside, rubrofusarin gentiobioside, and aurantio-obtusin (Figure 1) on vasopressin V1A receptor, 5-HT1A receptor, neurokinin receptor, and dopamine D3 receptor because these receptors were predicted as top protein targets of cassia-derived compounds in neurodegenerative diseases [45]. The gene discussed is AVPR1A; the disease is neurodegenerative disease.