At the same time, recent studies have shown that NLRP3 is highly expressed in the lungs, which is due to the large number of immune cells characteristic of this organ, and emerging scientific evidence suggests that the activation of NLRP3 inflammasome may be involved in the onset of COPD pathogenesis [173,174,175,176]. This evidence concerns the gene NLRP3 and chronic obstructive pulmonary disease.