RRM2 and Familial prostate cancer: For instance, BCR-ABL in chronic myelogenous leukemia (CML) [5], TMPRSS2-ETS [6,7], SLC45A3-ELK4 [8,9,10,11], and D2HGDH-GAL3ST2 in prostate cancer [12], LHX6-NDUFA8 and SLC2A11-MIF in cervical cancer [13], RRM2-C2orf48 in colorectal cancer (CRC) [14], and ASTN2-PAPPAas in esophageal cancer [15].