Of note, these ApoB100-autoreactive CD4+ T cells are mainly comprised FoxP3+ Tregs in healthy individuals, whereas in patients with subclinical atherosclerosis, they are comprised less of Tregs and more of T-bet+ Th1 and retinoic-acid receptor-related orphan receptor (ROR)-γt+ Th17 cells. This evidence concerns the gene APOB and atherosclerosis.