LDLR and systemic lupus erythematosus: Other autoantigens, such as heat-shock proteins (HSPs) 60/65, have been detected in atherosclerotic plaques [24,25], and the transfer of effector T cells from MRL-lpr mice, which develop an autoimmune disease resembling systemic lupus erythematosus (SLE), into Ldlr−/− mice has been shown to increase atherosclerosis [26].