Interestingly, immunization of Ldlr−/− mice with multi-antigenic epitopes from ApoB100, hHSP60, and Chlamydophila pneumoniae, with alum as adjuvant, was more effective in inhibiting atherosclerosis than single- or bi-epitope vaccine, associated with a stronger specific Treg response [105]. The gene discussed is APOB; the disease is atherosclerosis.