Out of the ones detected, IL-11 (C: 2.07 ± 0.51 vs. L: 2.64 ± 0.65 pg/mL; 95%CI: C: 1.65–2.68 vs. L: 2.31–2.96 pg/mL), IL-28A (C: 39.98 ± 5.61 vs. L: 46.17 ± 6.65 pg/mL; 95%CI: C: 35.41–44.57 vs. L: 42.98–49.37 pg/mL) and IL-29 (C: 74.13 ± 20.58 vs. L: 96.19 ± 29.1 pg/mL; 95%CI: C: 58.62–89.66 vs. L: 82.22–110.2 pg/mL) were significantly increased in the serum of lipedema patients (Figure 4B–D). This evidence concerns the gene IL11 and Lipedema.