The application of unfractionated heparin or low-molecular-weight heparin Tinzaparin completely blocked platelet aggregation for 60 min (Figure 5C,D) and corroborated our previous assumption of a two-pronged platelet activation mechanism consisting of P-selectin and thrombin generation induced by AsPC-1 and Capan-2 pancreatic cancer cells. This evidence concerns the gene SELP and familial pancreatic carcinoma.