EIF2AK4 and hydrops fetalis: The net impact of eIF2α phosphorylation on VH/HF is the subject of conflicting reports; activation of GCN2 with the drug halofuginone, or up-regulation of eIF2α phosphorylation with the phosphatase inhibitor salubrinal, have been found to protect the heart from pressure overload [511,512,513,514,515]—whereas mice with genetic knockout of GCN2 have also been reported to be protected in this regard [516].