CASP8 and immunodeficiency disease: In human T cells, caspase-8 serves as a link for the CARMA1-Bcl10-MALT1 (mucosa-associated lymphatic tissue) (CBM) and IKK complex to induce NF-κB activation [66], and an inherited genetic deficiency of caspase-8 in human leads to immunodeficiency by impaired activation of T, B, and NK cells [68].