CASP8 and Yersinia infectious disease: In addition, macrophages from ripk3/casp8 double knockout mice or mlkl/casp8 double knockout mice showed less cytokine induction upon Yersinia infection and TLR stimuli, such as LPS, Pam3CSK, CpG, and polyinosinic:polycytidylic acid (Poly[IC]) [76,77].