Recently, testosterone has received great attention even in the context of the COVID-19 pandemic for its effects on the general health status and for modulating the transmembrane serine protease 2 (TMPRSS2), which plays a crucial role in the entry of the SARS-CoV-2 virus into the respiratory epithelial cells leading to the COVID-19 disease [24,25]. The gene discussed is TMPRSS2; the disease is COVID-19.