E2F8 is still poorly characterized in the context of brain tumors but it has been implicated in the development of various cancer types including lung cancer, lymphoma, colon cancer, cholangiocarcinoma, prostate cancer, hepatocellular carcinoma and breast cancer [96,97,98,99,100,101,102,103,104,105]. The gene discussed is E2F8; the disease is breast carcinoma.