CCL3 and neoplasm: Among the DAMPs due to the tumor presence, the extracellular accumulation of ATP is slowly hydrolyzed by GBM [84] and promotes the expression of macrophage inflammatory protein-1alpha (MIP-1α) and MCP1 in microglia and macrophages via purinergic receptor X7 (P2RX7) in a Ca2+-dependent mechanism [85].