IL2 and neoplasm: M1 profile is signed by the expression of the signal transducer and activator of transcription 1 (STAT1), the pro-inflammatory cytokines interleukin-1beta (IL-1β), interleukin-2 (IL-2), interleukin-12 (IL-12), TNF-α, interferon-gamma (IFN-γ), a disintegrin and metalloproteinase (ADAM)-10, ADAM-17 and phagocytic functions, and drives the anti-tumor response.