Evidence shows that microglial interleukin-6 (IL-6) signals the reactive astrocytes for reaching the peritumoral area and releasing Monocyte Chemotactic Protein-3 (MCP-3) via JAK-STAT proteins, attracting microglial cells, thus triggering a positive loop between microglia and astrocytes at the tumor site [147]. The gene discussed is SOAT1; the disease is neoplasm.