Such an approach, although it has several limitations, give us the opportunity to examine in a simple model the possibility of using the promoters of the genes with a high level of expression in the stroma (FAP, CXCL12, IGFBP2, CTGF, JAG1, SNAI1, SPARC) as elements for transcriptional targeting of gene expression in tumor fibroblasts. The gene discussed is SNAI1; the disease is neoplasm.