Up until now, FDA approved PD-1 and PD-L1 checkpoint inhibitors for melanoma, renal cell carcinoma, head and neck cancer, urothelial carcinoma, CRC, hepatocellular carcinoma, small and non-small cell lung cancer, esophageal squamous cell carcinoma, cervical cancer, Merkel cell carcinoma, bladder cancer, certain types of endometrial carcinoma, and breast cancer. This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.