TNF and sarcopenia: Honokiol is another main ingredient of M.C, and is also expected to alleviate sarcopenia for three reasons: (1) honokiol has the ability to cross the blood–brain barrier and has high oral bioavailability; (2) honokiol inhibits NO and TNF-α expression, as well as PKCα, NF-κB, and MAPK signaling pathways [36]; and (3) honokiol saves skeletal muscle wasting by inhibiting NF-κB inflammation and induced oxidative stress [7].