SMAD3 and neoplasm: In tumor-intrinsic hypoxia-induced migration, out of the hypoxia (Figure 3E), EMT (Figure 4C), and directional migration gene signatures (Figure 5E), eight genes were common between hypoxia and EMT gene signatures (TNFAIP3, VEGFA, JUN, LOX, TGFBI, PLOD2, CXCL12, THBS1), 12 genes were common between hypoxia and migration signatures (VEGFA, JUN, NOS3, EFNA1, PRKCA, SIRT1, THBS1, CITED2, CXCL12, SMAD3, CXCR4 and ICAM1), and eight genes were common between EMT and migration gene signatures (VEGFA, JUN, PFN2, ECM1, LRP1, TIMP1, CXCL12, and THBS1).