Patients with a clinical response (SD/PR) had low basal levels of ECM proteins like epithelial cadherin (E-cadherin), intercellular adhesion molecule 1 (ICAM-1) and osteopontin (OPN) after 3 weeks of treatment, as detected by enzyme-linked immunosorbent assay (ELISA) in plasma from CRC, ovarian, HCC, renal, lung, cervical, endometrial, neuroblastoma, and peritoneal cancer patients [200]. The gene discussed is SPP1; the disease is neuroblastoma.