The growth of Lewis lung carcinoma xenografts is compromised in ENG haploinsufficient mice (Eng+/−), in which tumor vascularization is dampened relative to their wild-type (Eng+/+) littermates (as measured by capillary density, hemoglobin content, and vascular cell adhesion molecule-1 (VCAM-1) expression), in association with reduced eNOS phosphorylation [151]. Here, ENG is linked to neoplasm.