Evidence suggests an anti-angiogenic function for Sol-ENG in cancer and, indeed, the ENG extracellular domain fused to an immunoglobulin Fc domain (ENG-Fc) that mimics Sol-ENG reduces in vitro and in vivo angiogenesis and inhibits tumor growth in a xenograft model of CRC [33,183] (Figure 2). This evidence concerns the gene ENG and neoplasm.