IL4R and allergic disease: In addition, one-sixth of the top 37 differentially expressed genes were associated with the development of type 2/Th2 immune responses and the pathogenesis of allergic diseases, with increased gene expressions of IL13RA1, PLAUR, THBD, ICAM1, VEGF, and CD74. IL13RA1 encodes the IL-13Rα1 protein, which, in conjunction with IL-4Rα, forms the IL-13 receptor.