Other pathways that can explain the low amount of 5hmC in tumor DNA include: (a) passive dilution by cell division in the presence of defective activity of DNA methyltransferase 1 (DNMT1); (b) changes in TET activity as a consequence of gene mutations (see Section 6.2) or TET protein “de-localization” [150,151]. Here, DNMT1 is linked to neoplasm.