Indeed, a case study on eight cancer patients with advanced stage malignancies characterized by defects in the homologous recombination repair system showed that I.V. vitamin C in combination with PARP inhibitors (niraparib or olaparib or talazoparib) induced 37.5% complete remissions (3 patients out of 8) and 62.5% (5 patients out 8) partial responses [202]. The gene discussed is PARP1; the disease is cancer.