The novel observations from this study reveal: (i) elevated levels of TNC and FGB in exosomes from plasma of COVID-19 patients and (ii) COVID-19 exosomes enhance expression of pro-inflammatory cytokines TNF-α, IL-6, and chemokine CCL5 through the NF-κB signaling pathway upon exposure to hepatocytes, as a model for cells from distant organs. Here, TNF is linked to COVID-19.