Beyond their cholesterol-lowering potentials, marine sterols are shown to have therapeutic promise against AD by protecting against apoptosis, oxidative stress, and neuroinflammation through modulating cell survival pathways, such as brain-derived neurotrophic factor (BDNF), nuclear factor erythroid 2–2-related factor 2 (Nrf2), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling systems [11]. The gene discussed is BDNF; the disease is Alzheimer disease.